So in this case, arent the two factors a) physical possession of desktop/laptop and b) the Yubikey ? How likely is it you'll lose both if you keep your keyring with you?
Not sure reading the article why would I need the computer. The way I read it, you enter the key to any computer and it logs in to the account of the key owner. Am I wrong?
FTA: "Organizations will soon have the option to enable employees and customers to sign in to an Azure AD joined device with no password, by simply using a Security Key to get single sign-on to all Azure AD based applications and services."
Emphasis added. Device needs to be paired with Company's AD first.
I also imagine that there are options for making e.g. the device unlock only require yubikey, but login to SSO require 2nd factor.
What you need is a mechanism to detect loss of contact with the human and revoke. One way is to require several hardware tokens to combine their entropy to authenticate. Again, don't make a password be a part of this, use another token.