Sure-advantages include a great mixture of being near to much of Europe, a short train ride from the alps (I do lots of hiking in the summer, skiing in the winter), very high salaries, no poverty, great universities, intense work ethic, etc. I don't by any means need a car, and if I did there's Mobility (the Swiss analog to Zipcar).
Disadvantages include having an older population, being small compared to New York, having less of a startup culture than SF, being very expensive, having many hurdles to get a residency permit for an American, and various innocuous cultural differences that simply take getting used to.
If anyone else is interested in Zurich startups, Zattoo (a household name in Switzerland) is hiring engineers in Zurich (the rest of the engineering team is in Ann Arbor, MI): http://zattoo.com/en/jobs
