I just checked the app store on my Mac. I have just 1 application installed from the app store: Xcode. Even then that's just because Apple makes me have it installed to have command line tools such as git.
I think it's safe to say that the vast majority of applications (Microsoft Office, games, browsers, text editors, IDEs, etc.) installed on Macs are sourced from places other than the app store.
I think it's safe to say that the vast majority of applications (Microsoft Office, games, browsers, text editors, IDEs, etc.) installed on Macs are sourced from places other than the app store.