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> trying senolytic drug candidates in rational self-experimentation

> senolytic drug candidates, dasatinib plus quercetin if you're fine with short burst of chemotherapeutics, or FOXO4-DRI

How does one go about self-experimentation? FOXO4-DRI is for sale on the internet, but one needs a doctor to read the mouse studies and formulate a treatment plan. The same goes for dasatinib plus quercetin. In the mouse models it needs to be administered monthly. Is there a country one can visit today that has access to these peptides and drugs and willing doctors to create a plan?




I'll get to publishing a detailed essay on that topic at some point in the near future. The less detailed precursor overview can be found here:

https://www.fightaging.org/archives/2017/05/planning-a-singl...

You don't need a doctor to figure out a treatment plan, you just need to put in some time to get familiar with reading research papers, the terminology, how researchers describe things, and the methodology used to move from animal to human exploratory studies. And an understanding of the risk - as doctors are usually pretty bad at explaining that in any case. It really isn't rocket science, and it is all copiously documented in scientific and other literature.

Also D+Q isn't administered monthly, it is a one-off treatment that, assuming it works in humans in the same way it does in mice, certainly wouldn't need to be done more than once every few years. It removes the cells it can remove, and then isn't going to do any more until new senescent cells arise at their slow pace. The people out there taking it frequently as though it were a supplement are just not acting sensibly, and don't understand the research.




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