Pedestrian-only town centres are getting pretty common.
I can't speak for Ghent but it's fairly normal to have periods, early morning or late evening, where goods vehicles are allowed access.
It's worth bearing in mind that the centres of a lot of European towns and cities are fairly small and not very vehicle friendly anyway. One of the advantages of being pre-industrial is that it can take less work to be pre-industrial again. I'd expect that, in general, doing this is the US will be harder than a lot of Europe as the towns just aren't built that way.
I can't speak for Ghent but it's fairly normal to have periods, early morning or late evening, where goods vehicles are allowed access.
It's worth bearing in mind that the centres of a lot of European towns and cities are fairly small and not very vehicle friendly anyway. One of the advantages of being pre-industrial is that it can take less work to be pre-industrial again. I'd expect that, in general, doing this is the US will be harder than a lot of Europe as the towns just aren't built that way.