I use uBlock Origin plus uMatrix but I have to say that it's probably only for people who are really serious about security. It breaks nearly every site by default.
This really depends on the lists that you use in each. Research exactly what you want to block. I personally don't like a few of the lists for that specific reason, they block everything all together, not just tracking pixel domains and things of that nature. There is also an official uBlock Origin Extra extension that I find very handy for blocking websocket garbage. This is becoming more important as websocket connections become more prevalent. https://github.com/gorhill/uBO-Extra/wiki/Sites-on-which-uBO...
I wonder this, too. I use uBlock Origin in medium mode (advanced settings available, no third-party scripts or frames until enabled), and it seems to do what's needed. It breaks a lot of things, but also makes it easy to fix them.
