EDIT: I just realized you said "Isn't MPC-HC for Windows, and Brew for macOS?" which threw me off.
I am currently on Windows and use MPV, I don't see why it should be exclusive in any way.
The dotfiles are compatible, and same goes for lua scripts. So there's no trade off at all that I've found. And it's nice to be able to just clone my dotfiles and have it work in OS X, and same for Windows.
I agree. MPV is very customisable, and it's great to have a video player that works just how you want it, regardless of the system you're using.
EDIT: Yeah, I was just pointing out the fact that, if you're using MPC-HC, then you're probably using Windows. In which case, whilst MPV is a good alternative, you wouldn't be installing it with (Home)brew, which is a package manager for macOS.
I am currently on Windows and use MPV, I don't see why it should be exclusive in any way.
The dotfiles are compatible, and same goes for lua scripts. So there's no trade off at all that I've found. And it's nice to be able to just clone my dotfiles and have it work in OS X, and same for Windows.