Causations are not necessarily one way. Inflammation causes disease, disease causes obesity (unhealthy people tend to move less), obesity causes more inflammation. Start anywhere in the circle.
I don't believe there's actually any evidence for the
claim that inflammation is the root issue for most disease
Inflammation forms the basis of many physiological and
pathological processes. Much is known about how
inflammation is initiated, develops and resolves over the
short term. But less is known about the causes and
consequences of chronic inflammation, which underlies many
human diseases. Recent studies have extended our
understanding of chronic inflammation and the cross-talk
that occurs between inflammatory responses and other
physiological and pathological
This is common knowledge and has been for a long time.