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https://www.youtube.com/watch?v=VdmbpAo9JR4#t=0m51s [warning, the view is jittery, due to being bumped around like a protein]

Also interesting things, just for scale: see a bacterium and a cell nucleus: https://www.youtube.com/watch?v=mdhk_-o8_n8

And an actual protein diffusion measurement from inside a nucleus (via light emitting proteins): https://www.youtube.com/watch?v=cDxUmCPxP_E

So, we're still some time from getting a "real" picture of the nucleus. Mostly because it's so dense.

(Here's a video about single particle tracking on the plasma membrane https://www.youtube.com/watch?v=dlq3kkbskaA and the nucleus is at least a magnitude more dense/busy.)

Life is very much about density gradients. Ion channels, osmotic pressure, and so on.

40% of the cytoplasm is proteins (by volume), which is remarkably high, considering a naive lattice packing is just 34% (the tetrahedral lattice with a density of).




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