On: Close-Up View of DNA Replication

[haskman]

That was amazing! Especially the machinery of the second part where the DNA strand is replicated backwards!

[pfd1986 → haskman]

Have a look at this lecture. It's really well explained, at a undergrad level, how the cell keeps the error rate low. Quite impressive, imo. https://youtu.be/DRBREvFL19g

[im3w1l → haskman]

That looks more error-prone, wonder if that copy has more mutations...

[Palomides → im3w1l]

yes, e.g. [1], but there are specialized repair mechanisms that operate at the same time, so the 'final' error rate is much lower than the 'initial' rate.

[1]: http://www.nature.com/nature/journal/v518/n7540/abs/nature14...

[ekianjo → im3w1l]

yeah I am wondering if there is any research on that particular matter.