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So given that neurons almost never divide (1), and other cell types like skin cells divide every few hours (2), based on your formulation how do we explain that we never find A-beta plaques in skin cells?

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1. It was thought that adult neurons didn't divided at all until like 1998; now we know some new neurons are produced from progenitor sources at very low rates.

2. 30,000 to 40,000 skin cells are produced every minute.




What matters is how many divisions away from the fertilized egg. The "mainstream" idea has lead to many paradoxes: https://www.ncbi.nlm.nih.gov/pubmed/25459141




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