This seems to be an unfair reading of that sentence. A fairer interpretation might be closer to "right tool for the right job". Certain topics or materials can be more easily understood when viewed with the right framework. In physics, for instance, calculus yields results that mere algebra and trigonometry cannot easily provide. It's not that calculus is easy, but that with it (the framework, point of view), the physics becomes easy.
EDIT: After reading more, I stand by this. And Grothendieck seemed to specialize in creating those frameworks.
Aside from frameworks looking at it right might have to come from years of study which may necessarily not be easy but once you find something easy you are looking at it right.
so I can measure my arrogance in nanoGrothendiecks, cute.