Well that depends in what's truly different for you. A quick example, because I'm on my phone, is [1], which is enabling donating to specific people around the world with total transparency through smart contracts
This is a perfect example of what I was talking about. It is a nice idea. However there are no problems charities face that existing FIAT currencies or bitcoin or standard real-world contracts don't already solve. Unless there is a case to be made that censorship or centralization is a problem for contracts in the charity space, this app is a solution looking for a problem, in my opinion.
It is unclear how blockchain smart contracts contribute any value to the users in this case.
There are a number of Islamic charities that have been prosecuted under suspicion of funding terrorism. Of course, as soon the government thinks Ethereum is being used to send money to ISIS, anyone associated with the project will be swiftly conveyed to Guantanamo Bay.
Do you have any examples of projects that would be truly different or impossible to implement without smart contracts?