I found that the killer application for Javascript would be to write github repos for Javascript wrappers for typescript. Seriously, why is CSS as Javascript objects a thing? Are we so bored with the stack we've been using that we can only make things interesting by cross compiling everything? It makes me think of this video: https://www.destroyallsoftware.com/talks/the-birth-and-death...
I really dislike writing styles as JavaScript objects, so styled-components let's you write actual CSS in JavaScript. We have also added support for a bunch of editors, so you don't miss out on syntax highlighting just because of that.
+1 for typestyle. My team and I have been using it for the past few weeks in trying to clean up a rather monolithic css project, and it's been really cool to work with.