WHen I started grad school in Biophysics (1995), a microscope professor mentioned adaptive optics and asked the incoming students if they thought similar processes could be done in microscopy. If you said yes, he let you join his lab (they were already working on this).
Were they working with some sort of fluid interface? Maybe layered liquids, or fluids that you don't want to dip an objective lens into? Or maybe temperature gradients?
I wonder if it would be possible to make a deformable mirror using a combination of liquid mercury chemically bonded with a ferromagnetic metal (if mercury isn't already magnetic). Then theoretically, you could use an electric current in a coil to shape the liquid into a precise shape.