Unfortunately, blocking that API (listening for 'wheel' events) will entirely break large portions of many sites -- any element where they've manually implemented the scrollbar or have fancy stuff or whatever won't work. I tried writing a Greasemonkey script that killed smooth scrolling, but it broke way too many sites.
One thing that does work though, at least in a lot of cases, is using an adblocker to block the URLs of common smooth scroll scripts. My adblock filter rules are in a comment in this gist if you want them (actually, this gist is my aforementioned Greasemonkey script): https://gist.github.com/oxguy3/ebd9fe692518c7f7a1e9
Of course, it would have to work seamlessly without breaking anything, so it might be asking a little much.