I do the exact same thing with multiple sites, using Asual's address plugin (which I love, btw... it also integrates with G Analytics perfectly). The only difficulty I have is getting people to use the non-hashed links instead of just copying what's in the address bar. Google treats all of the hashed links as the same link (everything up to the hash mark).
The other problem is people end up copying URLs like: http://alikewise.com/Profile/FounderGuy/Book/42#/Book/43
(edit: I noticed your site automatically forwards to the hashed version, which I also considered -- but it breaks the back button!)