Wow, thanks Allen for the clear suggestions. My initial thought is that we can do some of these. It would be awesome if we can have one less layer of horizontal navigation. I've created https://gitlab.com/gitlab-org/gitlab-ce/issues/20154 to follow up on this. If you or others have any more suggestions feel free to add them there as a comment.
Sure, thanks. I was trying to only change the issues page and stay within your overall layout.
Additionally I would probably move the user icon from the top right to the left and replace the hamburger, since the navigation below is really the user menu.