Sorry, I wasn't very clear. In my head I was thinking in terms of games that weren't ripped/downsampled to 'fit' on an 80min CD-R. I think the largest release was probably D2, which from memory needed 5x99min CDR's and even then numerous elements were downsampled/ripped/etc.
Bigger than Shenmue / Shenmue 2? IIRC both Shenmue games spanned 3 GD-ROMs.