Nope. If we're talking about tree-shaking (which we should be as it's the entire point in having static modules), you loose everything. That's because require(someRuntimeVariable) can refer to any module. So there's no way to exclude any of the node_modules, or any portions of any of them.
So all code in all modules must be kept. No tree-shaking for you.
So all code in all modules must be kept. No tree-shaking for you.