I use Quihoo (Total 360) antivirus and find it to be fast, well constructed and non-intrusive. I would like to hear a good reasoned argument why it isn't safe or secure to run it. I have looked into this matter a couple of time and was unable to find any evidence, aside from run of the mill "it's chinese" slander.
Can you uninstall Qihoo360's software easily nowadays? Four years ago I helped a friend to clean up his PC and it took me more than _two hours_ to remove numerous little pieces Qihoo had put in every corners of his system. I had to search the whole hard drive and the whole Windows registry, and delete them one by one manually. The feeling was like battling against something really evil.
I haven't had the need to uninstall it, but it hasn't given me the reason to either - at no point it made me feel like i was using something shady. It also has very little (and in a different forum i would use the word "none") in terms of the shareware aspects that are common to other free antiviruses. I've been using it for a while too, probably over a year.
Here's a 69-page long thread on an antivirus-themed forums that's been running since 2014:
I've been visiting it from time to time seeing whether the community attitude towards the product has changed for the worse, but so far it appears a lot of people use it.
Qihoo is listed at NYSE (went public in 2011), regulations and consumer protections are better enforced in many overseas markets than in China. I usually look for English version if I have to use software produced by certain Chinese software companies.