Some time ago I wanted to make a cross-platform app in python, I wanted to use the ui bindings of each platform, I had some success with Cocoa in OSX but when I tried in windows, I saw with IronPython I
could use WPF but when I tried to use it, it was reaally outdated and there wasn't even IronPython for python3... I guess it is no longer in active development... In the end I used swift in osx and c#
windows, but I would have loved to use .net apis in python and have the same codebase for all the platforms.
I was trying to port an app I already had in c# with wpf to be cross platform, so some networking code could be shared, but I could still use xaml and all the wpf work that I already had (although it wasn't that extensive, just tried for the sake of learning), I also used some audio apis, and with IronPython i could call c# code and use NAudio, so in the end I couldn't do what I wanted with just CPython
