A methylated B-complex vitamin would be prudent in most individuals as well to complement magnesium. Up to 50% of the population has a partially broken methylation cycle (in a form of C677T mutation).
I had back pain sleeping for a long time, fatigue, and tons of muscle twitching (even in supplementing magnesium and vitamin d), and a methylated b-complex effectively eliminated my symptoms.
The test to check for an MTHFR mutation is expensive, but supplementing a methylated high-quality b-complex isn't.
My brother found that he had this mutation via 23andme. Supplementing with 5-MTHF has changed both our lives, as well as my mother's (who was previously suffering from debilitating depression and anxiety).
Except if you do 23andMe you then have a legal obligation to provide any learnings to health insurance companies. Yeah, that's right, we live in a world that actively hinders being proactive about healthcare.
The B complex changed my life too -- relieved the fatigue I was feeling daily despite plenty of sleep, and gave me the energy to start better habits that pulled me out of a depressive episode.
I had back pain sleeping for a long time, fatigue, and tons of muscle twitching (even in supplementing magnesium and vitamin d), and a methylated b-complex effectively eliminated my symptoms.
The test to check for an MTHFR mutation is expensive, but supplementing a methylated high-quality b-complex isn't.