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What I would expect:

* fewer crappy apps running on startup

* improved startup time

* no unknown apps running after a clean boot

(Previous 3 can be monitored with e.g. SysInternals AutoRuns)

* no browser / networking stack hijacking extensions showing popups / interstitials / DOM modifications etc. at random intervals

(As evidenced by e.g. HijackThis)

* no unsigned DLLs / drivers of unknown provenance loaded in any process or the kernel

(As evidenced by e.g. Process Explorer's Verify Image Signatures option - look in loaded modules of the "System" process to see all loaded kernel drivers and modules), with a representative sample of applications running (browsers, productivity, etc.)

* no apparent rootkit-style hijacking of the process / registry / disk inspection routines, as would be shown by e.g. RootkitRevealer

And of course, a commercial virus scan, for what it's worth. I personally don't run a real-time virus scanner; I rely on monitoring what the system is doing directly.




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