IE 11 supports source maps, so that's helpful. The other nice thing is that you rarely end up dealing with browser specific quirks since all popular ClojureScript libraries piggie back on React.js and the Google Closure library.
These do a great job of handling the platform specific quirks for you. The first app I developed with Reagent actually had to run on IE8, and to my shock and surprised worked without any issues after I added the standard IE shims.
So, overall my experience is that you're better off dealing with IE than with most Js frameworks.
