Most of these "high-level" languages are more of "extensions" (CLOS certainly feels like an extension) or alternative lispish languages than bona fide DSLs with DS constraints (that can be used for DS optimizations). The S-expression syntax feels foreign/messy in many domains.
Tools like these are widely used in logistics domains, one of the domains where Lisp has been widely used. There is a competition between planning systems and PDDL is being used to describe the problems.
For a non-s-expression domain specific language on top of Lisp see for example PWGL. It uses a graphical language. Also Macsyma/Maxima, and many many many others.