25 years is a reasonable number for how long it took deep learning research to begin getting traction. I would think AI would be a strange choice since it seems like there are a lot of research opportunities in academia and industry for this topic, but for the same reason I would say AI research is ripe for disruption.
My bet is on renewable energy/sustainability, agriculture or biotech, with energy being my first choice. Sam has expressed serious concern about powering the future. His first(only?) deviations from the "No Board Seat" policy were two energy companies.
