That's unlikely, in my opinion. There are some seemingly fundamental aspects to the underlying mechanisms of life as we know it today and some aspects that are mostly just accidents of history. For example, RNA/DNA type systems and polypeptide proteins represent enormously powerful designs which seemingly can be bootstrapped from simpler systems. It would not be at all shocking to see other forms of life based on very familiar machinery. But if there were different details here and there, that too would also not be surprising.
Additionally, electrochemical gradients as a means of storing and using energy, and amphiphilic bilayer based membranes both seem to be incredibly fundamental, it would be more surprising to see life that was based on other principles than to see life that shared the same design. As for everything else, who knows? It's likely there are a ton of alternative design choices for a lot of different aspects of cellular machinery on up to large scale structures of plants, animals, fungi, etc.
But overall I'd rate some of the more "out there" notions of things like silicon or sulfur based life, or merely carbon-based life that was utterly different from our nucleic acid/protein/membrane based life as being comparatively unlikely.
Additionally, electrochemical gradients as a means of storing and using energy, and amphiphilic bilayer based membranes both seem to be incredibly fundamental, it would be more surprising to see life that was based on other principles than to see life that shared the same design. As for everything else, who knows? It's likely there are a ton of alternative design choices for a lot of different aspects of cellular machinery on up to large scale structures of plants, animals, fungi, etc.
But overall I'd rate some of the more "out there" notions of things like silicon or sulfur based life, or merely carbon-based life that was utterly different from our nucleic acid/protein/membrane based life as being comparatively unlikely.