> Obviously they don't (!) but the question is how?
Don't cells "just" orient themselves using mechanotransduction [1] or am I missing something? That's a bit hand wavey but since cells don't form 3d structures in tissue themselves, they orient against the extracellular matrix using mechanotransduction and other growth factors.
The development of multicellular life was essentially cells learning how to orient themselves into a digestive tract.
Don't cells "just" orient themselves using mechanotransduction [1] or am I missing something? That's a bit hand wavey but since cells don't form 3d structures in tissue themselves, they orient against the extracellular matrix using mechanotransduction and other growth factors.
The development of multicellular life was essentially cells learning how to orient themselves into a digestive tract.
[1] https://en.wikipedia.org/wiki/Mechanotransduction