IANAD but I’d imagine with all the knee/hip/everything replacements, metal plates in heads, pins in wrists, pacemaker implants etc that it’s a manageable issue.
I would point out for centuries, I’m thinking at least through the Industrial Revolution, 10-16 hours was the norm and many families were still raised. And it was horrible.
From reading upthread it sounds like performance impact is heavily dependent on the skill of the game development team, ie: if they pick the wrong things to hook during the in-game runtime checks performance can suffer greatly
For people who like exploring, know the leaning tower of Pisa is absolutely _not_ a once-in-a-lifetime experience. There are over 100 leaning towers around the world!
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