Re: Jiggy2011 - All game dev is hard-work; JS is easier in some ways, harder in others. We've had good 2D IDE's for 20 years now to make 2D games; Making the runtime HTML5 isn't new (especially with the ability to export SWF to JS with easel.js)
Re: CodeCube5 - We'll be covering perf on rendering, input, sound and overall entity processing
Re: muyuu - NaCl is awesome! Html5 is awesome! Web game development is a win either way; NaCl is great for devs who have an existing codebase, HTML5 generally works for most others.