I'm 23 and I just left my first job of two years to build a startup about three months ago. I'd like to believe that while you're young (if you are) and/or while you don't have to support anyone (e.g., a family), there's no reason why you shouldn't give it a try. If it doesn't pan out, you can always try again or just go back to having a regular job.
And I'll agree with some of the previous comments that all you really need to worry about is the money. Be sure that you can afford to not have any reliable income for a long while. Otherwise, if you think you have a good enough idea to pursue, just keep your morale up and you'll be fine.
I've had a few problems making it work like I want it to in IE when I have multiple replacements but otherwise it's fantastic. Although I can only get one replacement (all of my site's h2's) to work, my entire site just looked a whole lot better. I highly recommend it if you think you really need it. Just make sure you don't use it for substantial amounts of text.
Second that, we had tons of problems with IE and sIFR on a fairly large site - and it is only good in SMALL amounts.
We were doing the drop-down top navigation, the side navigation, footer links and some more aux links and it was slow as hell - I wouldn't recommend it if you can get by without it.
And I'll agree with some of the previous comments that all you really need to worry about is the money. Be sure that you can afford to not have any reliable income for a long while. Otherwise, if you think you have a good enough idea to pursue, just keep your morale up and you'll be fine.