There is a simple counter-example that proves that this is the wrong question to ask.
You cannot simply make a zygote with just the DNA from a sperm and an egg together alone. Both parents pronuclei are required for epigenetic reasons. If you try to do this, and the pronuclei are not present, then you will not make any viable offspring.
This is just one example of how oversimplified the model taught by the book is, though it is a useful one. The only thing that is certain is that we are not anywhere near being able to claim to know how many genes it takes to make a person.
Agreed. It's refreshing to read a justification to learn to enjoy such moments.
This is especially true in a society that tends to only place value on thoughts that directly lead to tangible means of moving forward. Sometimes, however, these moments of thoughtlessness can complement the aforementioned moments of intensity. This combination can actually lead to an overall net gain in achieving ones goals, whatever they may be.
A tough concept for the prototypical Type A personality to grapple with, no doubt. But something that is worth pondering.
I use these for coding/studying all the time. If you download all of them and put them on shuffle you basically have ~40 hours of music to jump into at any given moment.
I've been using the Anki iOS application for a while now. I'm considering moving my stack over to org-drill.el to minimze context switching. Anyone made a similar switch or can compare the two at all?
This is the reason I am pushing myself towards simpler solutions, even if I end up losing some functionality/connections out of it. The added cognitive load of dealing with managing all of these services is becoming really painful.
Yes, I may not have push via the cloud to my latest iGizmo, but at least I don't have to worry that I forgot an important calendar, todo, file, or chat message on one of 5 services that mix and match between what they offer.
Org-mode can run calendar, todo, notes, habits, journal, etc.
Chat is where I still haven't found a solution. Switching to XMPP/SMS semi-exclusively is probably the next step.
I would like that, but the thing with calendar, todos, etc, is that syncing with my iGizmo is what makes them most useful for me. That iGizmo is on my person at all times. At the doctor's office and need to make an appointment or talking to a contractor about getting away during the day to meet them at home? Calendar is right there so I won't schedule over a meeting or other engagement. Grocery shopping? My shopping list is there, no way I'd forget it at home. The syncing is precisely what I need it to do to be useful.
Before my iGizmo I carried around a notebook, but that was larger, more cumbersome and had less flexibility (I can add a grocery list item from my PC in the kitchen or even input it by voice if I realize I need something).
That means that for some of us, a better solution rather than a simpler one is what we desperately hope for.
The notoriety that this concept has managed to garner in the past 36 hours only secures the fact that a clone app (and however many more) will be made in a short period of time.
How much of an effect is removing the app really going to have?
No, it's just positioning in the wake of Snowden leaks. If it was a core philosophy/value that the company collective felt then this image wouldn't exist: https://imgur.com/iHEtqaE.jpg
Which is why I'm on board. I hope others take note so the "right to security and privacy" isn't only within reach of those who can afford Apple devices.
Many of these metabolic degradation products (not just beta-amyloid) of neuronal cell activities should readily be cleared quickly and efficiently from the interstitial space of the brain due to the highly sensitive nature of neuronal cells to their environment.
Some negative effects documented from these byproducts include: negatively effecting synaptic transmission[1], decreasing cytosolic Ca2+ concentrations[2] (Ca2+ is one of the final players in the triggering the release of neurotransmitters into the synapse between neurons to facilitate messages), and irreversible neuronal injury[3].
[1] - K. Parameshwaran, M. Dhanasekaran, V. Suppiramaniam, Amyloid beta peptides and glutamatergic synaptic dysregulation. Exp. Neurol. 210, 7–13 (2008)
[2] - K. V. Kuchibhotla, S. T. Goldman, C. R. Lattarulo, H. Y. Wu, B. T. Hyman, B. J. Bacskai, Abeta plaques lead to aberrant regulation of calcium homeostasis in vivo resulting in structural and functional disruption of neuronal networks. Neuron 59, 214–225 (2008)
[3] - M. P. Mattson, Calcium and neuronal injury in Alzheimer’s disease. Contributions of beta-amyloid precursor protein mismetabolism, free radicals, and metabolic compromise. Ann. N. Y. Acad. Sci. 747, 50–76 (1994)
You cannot simply make a zygote with just the DNA from a sperm and an egg together alone. Both parents pronuclei are required for epigenetic reasons. If you try to do this, and the pronuclei are not present, then you will not make any viable offspring.
This is just one example of how oversimplified the model taught by the book is, though it is a useful one. The only thing that is certain is that we are not anywhere near being able to claim to know how many genes it takes to make a person.