Sadly, this no longer really applies. Programmers today do absolutely grotesque things unimaginable to Knuth of that era. One look at any modern pipeline that converts to and from JSON a dozen times, sometimes even inside the same process between modules, would make Knuth recall all of that.
Programmers now have done the impossible: written code so consistently bad that there are no hotspots, because the whole codebase is non-performant trash.
Programmers now have done the impossible: written code so consistently bad that there are no hotspots, because the whole codebase is non-performant trash.