Maybe this is a joke and I'm taking it too seriously, but doesn't the Enterprise run on antimatter? I don't think we're going to be able to manufacture antimatter in large quantities in the next 20 years.
The Enterprise runs on Westinghouse nuclear reactors burning enriched U-235 (93%+). Also, the quoted price tag here seems steep when you could, quite literally, build the USS Enterprise 52 years ago for $451.3 million USD: http://en.wikipedia.org/wiki/USS_Enterprise_(CVN-65)