It’s primarily just due to the incredible scale of the region. It’s easily twice as large as any other, so any issues relating to scale appear there first and are fixed before they affect any of the other regions.
As in, most global services run primarily within us-east-1, and have only subsystems running in each region.
For example, it's likely that the actual master data stores for IAM are solely within us-east-1, but the key data is cached and services run in each region.
Similarly, Cloudfront is theoretically a global service, but only ACM certificates set up within us-east-1 can be used with Cloudfront.