I promise you, I felt the same way as you describe for years. I took antidepressants for years but they would eventually stop working. I tried all kinds of natural supplements, meditation, exercise, etc. After losing my marriage and alienating my children I tried once more but this time my doctor added a mood stabilizer. It has made all the difference in the world. I have a very close relationship with my children now, close friends, job, and enjoy many interests. Don't give up.